AC Immune is a leading Swiss-based biopharmaceutical company with three products in clinical trials.  We design, discover and develop therapeutic and diagnostic products to prevent and modify diseases caused by misfolding proteins. AC Immune’s two proprietary technology platforms create antibodies, small molecules and vaccines to address large markets across a broad spectrum neurodegenerative disorders.

Alzheimer’s disease (AD) is the largest indication addressed by our products but AC Immune’s innovative, highly differentiated and disease-modifying therapies are capable of shifting the paradigm in the treatment of other neurodegenerative diseases such as Down syndrome, Parkinson’s disease, Tauopathies, Glaucoma and Huntington’s. 

 The most advanced of these is crenezumab, an anti-Abeta antibody that is licensed to Genentech entering phase III development. Crenezumab was chosen by the US National Institute of Health for use in the first-ever AD prevention trial. The company has partnered three programs targeting Tau: ACI-35 with Janssen (therapeutic vaccine, phase Ib), Tau PET tracers with Piramal (Alzheimer’s diagnostic agent) and Tau-antibodies with Genentech (pre-clinical). The anti-Abeta vaccine ACI-24 phase I/IIa trial is run in house.

Alzheimer’s disease affects 47 million people worldwide and by 2030 this number will rise to 75 million at a cost of care of $408 billion. Current therapies have proven to be effective only for a limited period of time and do not significantly delay disease progression. In contrast, AC Immune’s therapies are designed to prevent, modify, delay or stop disease progression.